Name:Oxytocin
SynonymsOT;OXT;pitocin;OXTOCIN;Oxytocin powder;CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2;syntocinon;endopituitrina;pitons;OT-NPI
CBNumber:CB0366966
Molecular Formula:C43H66N12O12S2
Molecular Weight:1007.19
MDL Number:MFCD00076731
Melting point；192-194°C
alpha；D22 -26.2° (c = 0.53)
Density；1.1086 (rough estimate)
refractive index；1.6700 (estimate)
storage temp. 2-8°C
solubility；Very soluble in water. It dissolves in dilute solutions of acetic acid and of ethanol (96 per cent).
form；lyophilized powder
pka；pKa ～6.1(free amino group on Cys) (Occasionally);～10(free phenol on Tyr) (Occasionally)
color；White
Water Solubility Soluble in water.
Indications and Usage；
Oxytocin (OT) is a type of uterine contraction drug and can be derived from the animal posterior pituitary or chemically synthesized.
Oxytocin is a uterine contraction drug that is mostly used in late pregnancy induction and stagnant birth due to weak uterine contractions. Suitable for inducing labor and alleviating pain. Commonly used with ergot preparations to be used in inducing labor, expediting labor, and in uterine bleeding due to weak uterine contractions following birth or still birth. Nose drops can be used to promote lactation.
Mechanisms of Action
Oxytocin does not contain vasopressin and has no pressure-boosting effects. It can be absorbed through oral mucosa, selectively excite smooth uterine muscle, and intensify its contractions. The uterus is most sensitive to oxytocin when in labor (due to increased estrogen secretion), and an immature uterus will not respond to this drug. During early or mid-term pregnancy, the uterus has a relatively low reactivity to oxytocin, which gradually increases during late-stage pregnancy and peaks during labor. Small doses can strengthen the rhythmic contractions of smooth uterine muscles, increase their contractibility, increase their contraction speed, ensure similar contraction characteristics to that of a natural birth, and maintain polarity and symmetry. Thus, it is used clinically to expedite and induce labor. Large doses cause tonic contractions in the uterine muscles, so it is used clinically to burst blood vessels between muscle fibers, prevent postpartum hemorrhage, and ensuring postpartum recovery. It can also promote lactation by causing the breast ducts to contract and expel milk from the breasts, but it cannot increase the lactation amount.
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